heavy metals

Epilepsy, Seizures, and Toxicity: Why Are Childhood Seizures Increasing

Epilepsy is a chronic neurological condition characterised by recurrent, unprovoked seizures that start in the brain.

One single seizure or fit does not necessarily indicate Epilepsy, and a seizure can be caused by many factors.

Some types of seizures are more common in childhood, such as absence seizures which can be very brief —blink and you might miss it. It looks as though a child is ‘spaced out’, ‘daydreaming’ or not paying attention.

Learn how to help spot signs of seizures, so that you can get early treatment that may reduce the risk of lasting brain injury.

Symptoms of Seizures

Seizures is an abnormal, uncontrolled electrical discharge in the brain altering function or behavior. It is the most common neurological condition in children. Seizures can occur spontaneously or be triggered by things such as stress, excitement, boredom and tiredness. Anti-epileptic drugs can be used to control seizures and establishing good sleep patterns, as well as maintaining a healthy diet have also been shown to help manage the condition.

The International League Against Epilepsy (ILAE) classifies seizures based on the type of onset or where they originate in the brain.

Symptoms of seizures are widely variable but include stiffening (tonic) or rhythmic twitching (clonic) of one or more extremities or the face, staring spells, lip smacking or other non-purposeful movements or distinct periods of changes in behavior such as staring or sudden headache. In children on the autism spectrum, a sudden loss of languageskills or behavioral regression may be caused by epileptic disruption of organized brain activity that may not always show up clinically.

Between the time of the brain injury and the onset of seizures, called epileptogenesis, is a "silent" period because this brain abnormality cannot be detected by current neurological exams or electroencephalography (EEG). Before the actual observed seizure are brief, small electrical microbursts, or microseizures, occur before the onset of clinical recurrent seizures.

four main categories of seizures include:

• Generalized Seizures – affect entire brain
• Partial Seizures – affect part of the brain
• Non-Epileptic Seizures – not caused by epilepsy, but other things such as diabetes, fever, etc

Vaccines can cause fever, and fever in young children can lead to febrile seizures; these facts are not new. Febrile seizures are the most common seizure disorder of childhood and occur in ∼5% of all children, usually those younger than 24 months.
• Status Epilepticus – a seizure that lasts more than 5 minutes

Aside from neurosurgery, which benefits only a small population of Temporal lobe epilepsy (TLE) patients, there are no other effective treatments or preventive strategies.

Environmental triggers of epilepsy

Seizures are often unpredictable, but triggers can induce them, such as stress and environmental toxins. Being aware of potential seizure triggers helps avodid another occurance.

Anything that disturbs the normal pattern of the brain can trigger epilepsy. Trauma, illness, brain damage, abnormal development, food intolerances, and heavy metal toxicity can all be factors with epileptic patients. It is estimated that over 75% of patients with epilepsy do not know what is causing their seizure activity.

People with epilepsy are able to reduce the frequency of their seizure activity through dietary modifications and removing heavy metals from the body.

Certain food intolerances such as gluten (wheat, barley, rye, etc) casein (dairy), corn, or soy can be a major “triggers” for patients with epilepsy.

Heavy metal toxicity

Once of the most common ways that we experience heavy metal toxicity is through our teeth. Mercury fillings, gold crowns, and other metals that are placed in our mouth have the ability to “leak” into our bodies and accumulate in various organs, including the brain.

The brain and the Bazan effect

the brain consumes 20% of body oxygen and the central nervous system (CNS) is especially vulnerable to oxidative stress. Iron overexposure causes oxidative stress and ROS, which upregulate the c-fos gene.

Dr. Bazan is a neuroscientist who’s work influenced me while I was a resident at LSU and long before I had a quantum perspective.  Dr Jack Kruse shares extensively about his work; he was the first person who was able to link clinical diseases to the RPE in the retina by discovering what’s now called “the Bazan effect”. He was initially studying what effect seizures and lack of blood flow had on the CNS.  He found when the brain is stressed for any reason, neurons release two types of essential fatty acids, namely omega 6 and omega 3.  There names are arachidonic acid (AA) and docosahexonic acid (DHA).  These are essential FFA’s because the body has a poor capacity to make them endogenously.

Following this discovery, when they systemically administered Neuroprotectin D-1 (NPD1), they discovered that NPD1 regulated these bursts of brain electrical activity. So it not only reduced the aberrant brain cell signaling leading to severe generalized seizures, but also the spontaneous recurrent seizures. (Neuroprotectin D-1, discovered in the Bazan lab, is derived from docosahexaenoic acid (DHA), an essential omega 3 fatty acid found in fish oil.)

Resources

  1. Hironishi M., Ueyama E., Senba E. Systematic expression of immediate early genes and intensive astrocyte activation induced by intrastriatal ferrous iron injection. Brain Res. 1999;828:145–153. doi: 10.1016/S0006-8993(99)01356-6. doi.org/ [PubMed] [CrossRef] [Google Scholar]

Study: Toxic chemical exposure during pregnancy linked to serious health issues by elementary school

A study adds to the body of research showing that the mother’s exposure to toxins affects her child’s health well into the growing years. This study is one of the most comprehensive endeavors delving into early-life environmental origins of metabolic risk, further bolstering prior toxicological and epidemiological evidence in this area

Link to study: Prenatal Exposure to Chemical Mixtures and Metabolic Syndrome Risk in Children, jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.12040

the study

The researchers looked at 1134 mother-child pairs from 6 European countries (France, Greece, Lithuania, Norway, Spain, and the UK), and their prenatal exposures to common endocrine-disrupting chemicals (EDCs) mixtures. The mean age of the mothers at the birth of their child was 30.7 years, and they were recuited into the study April 1, 2003, and January 30, 2009.

These common toxic chemicals included “metals, organochlorine pesticides, polybrominated diphenyl ethers [that’s PBDEs, or flame retardants], and perfluoroalkyl substances”.

They then measured the children born to the mothers at 6 to 11 years of age. They focused on markers of metabolic syndrome, which combines measurements of blood sugars, lipids such as cholesterol, the existence of fat tissue and the impact on the heart.

We almost always consider health risks from single chemicals, one at a time, as if we are exposed to just one chemical at a time. Here the research team shows that children’s risk for cardiovascular disease and diabetes later in life can be driven by the complex mixtures of endocrine-disrupting chemicals in the body at any moment and it highlights the particular risk of chemical exposures during pregnancy. —Jane Houlihan, the national director of science and health for Healthy Babies Bright Futures

what the researchers found

They found that the exposure to toxins were associated with increased metabolic syndrome risk score and altered proinflammatory proteins, amino acids, and glycerophospholipid levels in childhood.

The childrens’ comprehensive tests had elevated levels of metabolic syndrome at ages 6 to 11. Metabolic syndrome can include obesity, elevated blood pressure, and abnormally high cholesterol and insulin resistance, which is a precursor to type 2 diabetes.

Within the group of children exposed to the highest levels of chemicals, 62% were overweight or obese, compared with 16% of children within the low-risk group.

Moreover, the levels of blood insulin and triglycerides, as well as systolic and diastolic blood pressure, were significantly higher in the high-risk group than in the low-risk group.

Pregnancy and childhood are especially important times to limit exposure to chemicals as the brain and body are in key stages of development. Sign up for a free guide to common pollutants AT HOME that you can reduce now.